Otamixaban for treatment of elderly and renal impaired non-ST elevation myocardial infarction patients

摘要

The invention relates to the use of (2R,3R)-2-(3-carbamimidoyl-benzyl)-3-[4-(1-oxy-pyridin-4-yl)benzoylamino]-butyric acid methyl ester or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in non-ST elevation myocardial infarction, said treatment comprising administering a therapeutically effective amount of (2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-[4-(1-oxy-pyridin-4-yl)benzoylamino]-butyric acid methyl ester or a pharmaceutically acceptable salt thereof to a human patient, who is elderly and/or shows renal insufficiency and/or has a low body weight.

主权项

1. A method of treating non-ST elevation myocardial infarction in a human patient in need thereof, comprising administering to said patient (2R,3R)-2-(3-carbamimidoyl-benzyl)-3-[4-(1-oxy-pyridin-4-yl)benzoylamino]-butyric acid methyl ester or a pharmaceutically acceptable salt thereof, in an amount between 0.070 mg/kg body weight/h and 0.105 mg/kg body weight/h of said patient, wherein the said patient is older than 75 years old and has non-ST elevation myocardial infarction.