| 摘要 |
Analgesic title compds. (I; A = pyrid-3-yl, isoquinol-5-yl, 3-alkyl isoquionol-5-yl) and their acid addition salts were prepd. by cyclization of II or reaction of III and IV(R1 = Cl, C1-4 alkylthio, benzylthio; A1 = Cl, I, SO3, tetra fluoroborate, flrorosulfate). Thus, 4.7 g II(A = pyrid-3-yl) in 50 cc 6N-Hcl was heated as 100oC, 30 min and was extracted with CH3Cl to give I. I was heated with 1.7 g fumaric acid under reflux to give I.fumarate(m.p. 150oC).
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