| 摘要 |
3-Azabicyclo(3.1.0)hexane-2-carbonitrile, a precursor for preparing 3-azabicyclo(3.1.0)hexane-2-carboxylic acid, a plant male gametocide, is prepared by (a) treating 3-azabicyclo(3.1.0)hexane with a chlorinating agent to form 3-chloro-3-azabicyclo(3.1.0)hexane; (b) treating a solution of that compound with a strong inorganic base and a lower alkanol, to give a solution of the corresponding 3-azabicyclo(3.1.0.)hex-2-ene; (c) treating the solution with an alkali metal bisulfite to form the 2-bisulfite adduct of 3-azabicyclo(3.1.0)hex-2-ene; (d) treating the reaction mixture containing the adduct with an alkali metal cyanide to form 3-azabicyclo(3.1.0)hexane-2-carbonitrile. |
