发明名称 PROCESS FOR THE PREPARATION OF PENICILLINS AND PENICILLIN DERIVATIVES
摘要 A process for the preparation of a compound of formula (I): <IMAGE> (I) wherein R1 is hydrogen, hydroxy, mercapto radical, a substituted or unsubstituted methoxy, ethoxy, methyl, ethyl, methyl thio, or ethylthio radical, a carbamoyloxy, carbamoylthio, C1-6 alkanoyloxy, C1-6 alkanoylthio, cyano, carboxy or carbamoyl radical; and R2 represents an acyl group which comprises hydrolysis of a compound of formula (II): <IMAGE> (II) wherein R1 and R2 are as defined with respect to formula (I) hereinbefore and R3 represents benzyl or substituted benzyl; wherein the hydrolysis is catalyzed by a microbial serine proteinase.
申请公布号 ZA8107317(B) 申请公布日期 1982.09.29
申请号 ZA19810007317 申请日期 1981.10.22
申请人 BEECHAM GROUP PLC 发明人 CHESTER IAN ROBERT;POWELL LAWSON WILLIAM;ROBERTS DAVID GLYN
分类号 C07D499/08;C12N11/08;C12N11/10;C12P37/00 主分类号 C07D499/08
代理机构 代理人
主权项
地址