| 摘要 |
PURPOSE:To prepare the titled substance, in high efficiency, by culturing yeast belonging to Saccharomyces genus, Candida genus, etc. in a methionine-containing liquid medium added with non-sulfur type amino acid or its salt. CONSTITUTION:Yeast belonging to Saccharomyces genus, Candida genus or Hansenula genus and capable of producing S-adenosylmethionine, e.g. Saccharomyces cerevisiae IFO2346, etc. is cultured in a methionine-containing medium added with a non-sulfur type amino acid devoid of sulfur atom in the molecule, e.g. glycine, methylglycine, L-alanine, L-leucine, L-aspartic acid, L-lysine, L-tryptophan, etc. at a concentration of >=0.02g/ml. The cultivation is carried out by conventional method under aerobic conditions, and the S-adenosylmethionine produced and accumulated in the microbial cell and/or cultivation liquid is separated therefrom. |
