PROCESS FOR THE MANUFACTURE OF HYDRAZONO-ISOINDOLINES

摘要

3-12754/+ Process for the manufacture of hydrazono-isoindolines The invention relates to a process for the manufacture of 1-hydrazono-isoindolines of the formula wherein Y is a methine or imine radical and the ring A can contain substituents which do not confer solubility in water, by reacting an iminoisoindoline of the formula with hydrazine or a hydrazine donor, in a polar solvent, which process comprises carrying out the reaction at tempertures below 80.degree.C. These hydrazono-isoindolines are obtained in excellent yield and purity and can be used without further purification as starting materials for further syntheses.