| 摘要 |
The antithrombic compds. I(W = Me-substituted vinylene, methylene or ethylene; m = 1, 2 ; D = C2-6 alkylene, C3-6 hydroxyalkylene, xylyene; R1 = H, or C1-3 alkyl; R2 = C3-6 cycloalkyl, C6-10 aryl, C7-11 aralkyl, N-and(or) O- or S-contg. heteroaryl or heteroaralkyl; R3,R4 = H, halogen, C1-4 alkyl, NH2, AcNH, NO2) were prepd. by the oxidn. of II (n = 0,1). Thus, a mixt. of 6-≮4-(2-pyridylmercapto)-butoxy≉-3,4-dihydro carbostyril 32.8 g, acetic anhydride 330 ml, and 35% H2O2 10.2 g was stirred for 15 hr at 20≰C to give 6-≮4-(2-pyridyl-mercapto)-butoxy≉-(3,4)-dihydrocarbostyril (m.p. 144.5-146≰C, yield 79.8%).
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