| 摘要 |
PURPOSE:To obtain an aniline derivative useful as a raw material for medicines and agricultural chemicals, by reacting an acetanilide derivative with water in the presence of a small amount of an acidic catalyst in an alcoholic solvent, and adding an alkali in an amount of gram equivalent equal to the acidic catalyst to the resultant reaction solution. CONSTITUTION:A compound of formulaI(R1 is H or halogen; R2 is halogen) is reacted with water in the presence of an acidic catalyst, e.g. hydrochloric acid or sulfuric acid, in an amount of 0.1g equivalent or less based on the above- mentioned aniline derivative in an alcoholic solvent at 140 deg.C or above, preferably 160-180 deg.C, and an alkali in an amount of gram equivalent equal to the acidic catalyst is added to the reaction solution to give the amied compound of formula II. The solvent is required to dissolve the compound of formulaI, water and hydrochloric acid and be stable to the acid and heat. n-Hexanol, ethylene glycol, etc. having >=140 deg.C boiling point is usually used as the solvent. |
