Heterocyclic compounds containing an alkoxycarbonyl and a substituted methyl group

摘要

The invention relates to new heterocyclic compound containing an alkoxycarbonyl and a substituted methyl group a process for the preparation of these and analogeous compound and pharmaceutical compositions containing them. More particularly, the invention concerns compounds of the general formula (IVa) <IMAGE> (IVa) wherein R' is hydrogen, 2-ethoxycarbonylethyl, aryl or a group suitable for a temporary protection of amides and Y' represents a group of the formula -COOZ or -CH2M, in which Z is lower alkyl and M is hydroxyl, halogen, cyano or a group of the formula -O-SO2R2, in which R2 is lower alkyl or aryl, with the proviso that if R' is phenyl, Y' cannot stand for the group -COOC2H5. The invention further relates to a process for the preparation of compounds of the general formula (IV) <IMAGE> (IV) in which R and Y are identical with R' and Y', respectively, except the proviso. According to a further aspect of the invention there are provided pharmaceutical compositions, first of all with antihypoxic activity, comprising compounds of the general formula (IVa) as active ingredient.