发明名称 |
LIPID VESICLES BEARING CARBOHYDRATE SURFACES AS LYMPHATIC DIRECTED VEHICLES FOR THERAPEUTIC AND DIAGNOSTIC SUBSTANCES, THEIR USE AND METHOD OF PREPARING THEM |
摘要 |
<p>Lipid vesicles comprising a lipid bilayer which includes analogs of cell-surface receptors such as dicetyl phosphate; stearylamine; 6-(5-cholesten-3 beta -yloxy) hexyl 1-thio- beta -L-fucopyranoside; 6-(5-cholesten-3 beta -yloxy) hexyl 1-thio- beta -D-galactopyranoside; 6-(5-cholesten-3 beta -yloxy)hexyl 1-thio- alpha -D-mannopyranoside; 6-(5-cholesten-3-yloxy)hexyl 2-acetamido-2-deoxy-1-thio- beta -D-galactopyranoside; 6-(5-cholesten-3 beta -yloxy)hexyl 6-amino-6-deoxy-1-thio- beta -D-galactopyranoside; or 6-(5-cholesten-3 beta -yloxy)hexyl 6-amino-6-deoxy-1-thio- alpha -D-mannopyranoside; cholesterol and distearoyl phospatidylcholine, and an effective amount of physiologically compatible radioactive tracer, cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to the human host and have been found to release the contents of the vesicles in a predetermined manner, i.e., controlled release, and in some cases, to be rapidly concentrated in the lymphatic system and/or liver, lungs or spleen of the host.</p> |
申请公布号 |
EP0028917(B1) |
申请公布日期 |
1984.05.30 |
申请号 |
EP19800303944 |
申请日期 |
1980.11.05 |
申请人 |
MERCK & CO. INC.;CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
BALDESCHWIELER, JOHN D.;GAMBLE, RONALD C.;MAUK, MARCIA R.;SHEN, TSUNG-YING;PONPIPOM, MITREE M. |
分类号 |
A61K51/00;A61K9/127;A61K47/00;(IPC1-7):61K9/50 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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