| 摘要 |
The present invention provides compounds of formula (1): …<CHEM>… and pharmaceutically acceptable acid addition salts thererof where… R<1> is 2- or 3-pyridyl optionally bearing one or two substituents which are the same or different and which are C1-4 alkyl, C1-4 alkoxy, halogen, nitro, cyano or trifluoromethyl;… a is 2 to 4; and… R<2> is phenyl optionally bearing one or two substituents which are the same or different and are halogen, hydroxy, C1-4 alkyl or C1-4 alkoxy or a methylenedioxy group or is 3-pyridyl; N-oxo-3-pyridyl; 6-methyl-3-pyridyl; N-oxo-6-methyl-3-pyridyl; 6-hydroxymethyl-3-pyridyl; 4,6-dimethyl-3-pyridyl; N-oxo-4,6-dimethyl-3-pyridyl; 6-hydroxymethyl-4-methyl-3-pyridyl; 5,6-dimethyl-3-pyridyl; N-oxo-5,6-dimethyl-3-pyridyl; 6-hydroxymethyl-5-methyl-3-pyridyl; 4-pyridyl or N-oxo-4-pyridyl. …<??>These compounds are useful as histamine H1-antagonists. |
