| 摘要 |
PURPOSE:To provide a body for selectively adsorbing and removing lipoprotein in blood by immobilizing a polyanion compd. having affinity to lipoprotein to a specific porous polymer hard gell. CONSTITUTION:A material prepd. by immobilizing a polyanion compd. consisting of heparin, sulfated polysaccharide such as dextran sulfuric acid, chondroitin polysulfate or the like and having high affinity to lipoprotein on a porous cellulose gel having 1,000,000-100,000,000 limit mol. wt. for removal of spherical protein, such as a synthetic high polymer such as a styrene-divinyl benzene copolymer, crosslinked PVA or the like and porous cellulose gel, at 0.02-100mg for each 1ml of column volume is used as an adsorbent body for selectively adsorbing and removing the lipoprotein (LDL) in the human blood, plasma or serum. The LDL which is a cause for arteriosclerosis is adsorbed and removed selectively at a low cost and said adsorbent body is used for the treatment of the hyperlipemia. |
