| 发明名称 |
A NOVEL SARS IMMUNOGENIC COMPOSITION |
| 摘要 |
Embodiments of the disclosure concern immunogenic compositions and methods for treating or preventing Severe acute respiratory syndrome (SARS). The compositions and methods concern a portion of the receptor-binding domain (RBD) of the SARS-CoV spike protein. In at least particular cases, a mutated version of a portion of the RBD is utilized, such as a deglycosylated mutant of the RBD. |
| 申请公布号 |
US2016376321(A1) |
申请公布日期 |
2016.12.29 |
| 申请号 |
US201415038726 |
申请日期 |
2014.11.21 |
| 申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
Hotez Peter Jay;Bottazzi Maria Elena;Zhan Bin;Chen Wen-Hsiang;Chag Shivali |
| 分类号 |
C07K14/005 |
主分类号 |
C07K14/005 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An isolated composition comprising the receptor-binding domain (RBD) of the Severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein, wherein said domain lacks at least one glycosylation site or is deglycosylated at least at one site that is glycosylated under normal conditions. |
| 地址 |
Houston TX US |
