| 摘要 |
The invention provides new cephalosporin derivatives of the general formula, <IMAGE> (I) which are in the form of a bicyclooct-2-ene or bicyclooct-3-ene, in which formula R1 is a radical of the general formula <IMAGE> (II) [in which R5 is hydrogen, alkyl, vinyl, cyanomethyl, protected carboxyalkyl or a protective radical and R6 is a protective radical] or an amino-protecting radical, R2 is an acid-protecting radical and R DEG represents various organic radicals, or alternatively R1 is an amino-protecting radical or various acyl radicals, R2 is a protective radical and R DEG represents various organic radicals, and R3 and R4 are alkyl radicals optionally substituted by alkoxy or dialkylamino, or phenyl radicals, or -NR3R4 forms a heterocyclic ring. These products are intermediates for the synthesis of cephalosporins having antibacterial activity. |
