| 摘要 |
FIELD: medicine.SUBSTANCE: disclosed is a combination immediate/delayed release delivery system for compounds which have short half-life, such as antidiabetic remogliflozin etabonate, which provides a dosage form that has two distinct phases of release. Solid phase for immediate release includes remogliflozin etabonate and immediate release material. Solid phase of delayed release comprises remogliflozin etabonate and sustained release material. Solid phase of delayed release has shape of discrete single particles or granules and solid phase for immediate release is a matrix, which consists of separate particles of solid phase of delayed release enclosed in said matrix or dispersed therein. What is also presented is a method for producing a pharmaceutical composition.EFFECT: invention provides a procedure for administering remogliflozina etabonate once a day.9 cl, 4 dwg, 4 tbl, 2 ex |
