Process for the preparation of 2-(trialkylsilyl)ergoline derivatives

摘要

A novel process for the preparation of 2-(trialkylsilyl)ergoline derivatives of the general formula <IMAGE> in which C8---C9 and C9---C10 denote a CC single bond or a C=C double bond, but not a cumulated double bond, and the substituent in the 8-position is a- or b- if C8---C9 denotes a CC single bond, R denotes C1-4-alkyl, R<6> denotes C1-3-alkyl, and R<8> denotes methyl or the group NH-CO-NEt2 or NH-CS-NEt2 and their salts is described by rearrangement of a 2-bromo-1-(trialkylsilyl)ergoline. The compounds according to the invention have biological activity in the central nervous system field.