PROCESS FOR THE PREPARATION OF PHENYLALKYLAMINES

摘要

Compd. of the formula (I) [R1=OH, C1-3 alkanyl, amino gp. substd. by C2-4 alkoxycarbonyl, alkylamino, dialkylamino; R2,R3= halo, CF3, CN, NO2, H; R4=H, C1-3 alkyl; R5=H, C1-4 alkyl, C3-6 cycloalkyl, C2-5 alkenyl, C7-10 aralkyl; A=CH2, CH2CH2, HOCH; B= CHR8(CH)2DC6H6(R6) (R7) or EC6H6(R6)(R7); R6=H, halo, OH, C1-3 alkoxy, C1-3 alkyl, sulfenyl or alkylsulfynyl; R7=H, OH, C1-3 alkoxy; R6=R7=methylenedioxy; R8=H or C1-3 alkyl; D=O,S,SO3,SO4; E=C3-5 alkylene, etc! were prepd. Thus, 0.5g Na8H4 was treated with a soln. of 3.45g 4'-amino-3',5'-dichloro-2-[N-3-[(4-methoxyphenyl)- propyl!methylamino! acetophenone at pH of 3-6 to give 1(4-amino-3,5- dichlorophenyl)-2-[N-3-(4-methoxyphenyl)-propyl! methylamino!ethanol.