Antihypertensive thieno-isoxazoles and -pyrazoles, a process and intermediates for their preparation and their use as medicaments.

摘要

There are described compounds of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="34" wi="70" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>where X is O or NR, R being hydrogen or loweralkyl; R, is hydrogen; and R<Sub>2</Sub> is loweralkyl, arylloweralkyl, aryloxylo- weralkvl or loweralkvl substituted with
<Chemistry id="chema02" num="0002"><Image id="ia02" he="17" wi="70" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or alternatively -NR<Sub>1</Sub>R<Sub>2</Sub> taken together is
<Chemistry id="chema03" num="0003"><Image id="ia03" he="11" wi="28" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>R<Sub>3</Sub> being arylloweralkyl or a pharmaceutically acceptable acid addition salt thereof, which are useful as ocular or systemic antihypertensive agents.