(N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade.

摘要

The present invention relates to N-substi­tuted 2-hydroxybenzamide and N-substituted 2-hydroxy-­α-oxo-benezene acetamide having the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="36" wi="94" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> wherein
y one or two is
R₁ and R₅ represent a hydrogen atom or a substituent
b is zero to four
and
R₆ is an alkyl group having 6 to 20 carbon atoms, an eventually substituted aryl or aralkyl group or a group CH=CHR₄ or (CH₂)<Sub>n</Sub>-CO-R₄ in which R₄ represents an eventually substituted phenyl group.
These compounds are usefull for the treatment of diseases in which products having lipoxygenase enzyme activity contribute to the pathological condition. Selected novel intermediates are also the present invention.