Dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection

摘要

The invention provides novel compounds having the general formula:;
wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.

主权项

1. A compound of formula IA, wherein R1 is hydrogen, halogen or C1-6alkoxy; R2 is hydrogen, halogen, C1-6alkyl, C1-6alkoxy, C3-7cycloalkyl, hydroxy or phenyl-CxH2x—O—; R4 is hydrogen or halogen; R5 is hydrogen or C1-6alkyl; R6 is hydrogen; C1-6alkyl, which is unsubstituted or once, twice or three times substituted by fluoro; C3-7cycloalkyl; C1-6alkylC3-7cycloalkyl; or phenyl-CxH2x—; R7 is hydrogen; C1-6alkyl, which is unsubstituted or substituted with one to three substituents independently selected from fluoro, hydroxy and ethenyl; C1-6alkoxyC1-6alkyl; C1-6alkoxyC1-6alkoxyC1-6alkyl; aminoC1-8alkyl; C1-6alkylcarbonylaminoC1-8alkyl; C1-6alkylsulfonylaminoC1-8alkyl; C1-6alkylsulfanylC1-6alkyl; C1-6alkylsulfonylC1-6alkyl; cyanoC1-6alkyl; C3-7cycloalkylC1-6alkyl; cyanoC3-7cycloalkylC1-6alkyl; phenylC1-6alkyl; pyrrolidinylcarbonylC1-6alkyl; C2-6alkynyl; hydroxyC1-6alkylC2-6alkynyl; aminoC1-6alkoxyC1-6alkyl; C1-6alkylaminoC1-6alkoxyC1-6alkyl; carboxyC1-6alkyl; C1-6 alkoxycarbonylaminoC1-8alkyl; heteroarylC1-6alkyl, wherein heteroaryl is N-containing monocyclic heteroaryl; or heterocycloalkylC1-6alkyl, wherein heterocycloalkyl is monocyclic heterocycloalkyl; x is 1-6; or pharmaceutically acceptable salts, or enantiomers thereof.