| 主权项 |
1. A compound of formula I wherein: R1 is selected from the group consisting of C1-6-alkyl, C2-6-alkenyl, C3-7-cycloalkyl-CH2—, phenyl-CH2—, C3-7-cycloalkyl, and phenyl, wherein each C1-6-alkyl and C3-7-cycloalkyl group is optionally mono- or polysubstituted with F and optionally substituted with one or two groups independently selected from H3C—, FH2C—, F2HC—, F3C—, and HO—; one CH2 unit of the C3-7-cycloalkyl groups is optionally replaced with one O atom; and each phenyl group is optionally substituted with one or two groups independently selected from F, Cl, H3C—, F3C—, NC—, H3C—O—, and F3C—O—; (Het)Ar is selected from the group consisting of:
a) phenyl, tetrazolyl, pyridinonyl, and a 5- and 6-membered heteroaromatic ring which contains 1, 2, or 3 heteroatoms independently selected from N, NRN, O, and S, wherein each phenyl, pyridinonyl, and heteroaromatic ring thereof is optionally substituted with one or more substituents independently selected from LAr and each phenyl, tetrazolyl, pyridinonyl, and heteroaromatic ring thereof is optionally substituted with a group T; andb) 1,2,3,6-tetrahydropyridin-4-yl which is substituted at the N atom with a —S(═O)2—C1-6-alkyl or —S(═O)2—C3-6-cycloalkyl group, wherein the alkyl and cycloalkyl groups thereof are optionally substituted with one or more substituents independently selected from F, Cl, CN, OH, and C1-3-alkyl-O—; RN is independently selected from the group consisting of H, C1-4-alkyl, C1-4-alkyl-C(═O)—, and C1-4-alkyl-S(═O)2—; T is selected from the group consisting of F, Cl, Br, I, CN, OH, NO2, C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkynyl-, C3-6-cycloalkyl, C1-6-alkyl-O—, C3-6-cycloalkyl-O—, C1-6-alkyl-S—, HO—C(═O)—, C1-6-alkyl-O—C(═O)—, C1-4-alkyl-C(═O)—, C3-6-cycloalkyl-C(═O)—, C1-4-alkyl-S(═O)—, C1-4-alkyl-S(═O)2—, RNT1RNT2N—, RNT1RNT2N—C(═O)—, RNT1RNT2N—S(═O)2—, RNT1RNT2N—C(═O)—(RN)N—, heterocyclyl, heterocyclyl-O—, aryl, aryl-O—, heteroaryl, and heteroaryl-O—, wherein each alkyl, alkenyl, alkynyl, and cycloalkyl group is optionally substituted with one or more substituents independently selected from F, Cl, CN, OH, C1-3-alkyl, C3-6-cycloalkyl, C1-3-alkyl-O—, RNT1RNT2N—, RNT1RNT2N—C(═O)—, C1-4-alkyl-S(═O)—, C1-4-alkyl-S(═O)2—, RNT1RNT2N—S(═O)2—, aryl, heteroaryl, and heterocyclyl; aryl is phenyl or naphthyl; heteroaryl is a 5- or 6-membered aromatic ring which contains 1, 2, 3, or 4 heteroatoms independently selected from N, NRN, O, and S; heterocyclyl is a 4- to 7-membered unsaturated or saturated carbocyclic ring in which 1, 2, or 3 —CH2— groups independently are replaced by NRN, O, —C(═O)—, S, —S(═O)—, or —S(═O)2—, and/or in which a —CH— group is replaced by N; and each aryl, heteroaryl, and heterocyclyl group is optionally substituted with one or more substituents independently selected from LAr; RNT1 is selected from the group consisting of H, C1-6-alkyl, C3-6-cycloalkyl, C1-6-alkyl-C(═O)—, C1-4-alkyl-NH—C(═O)—, (C1-4-alkyl)2N—C(═O)—, C1-6-alkyl-S(═O)2—, heterocyclyl, aryl, and heteroaryl, wherein each alkyl and cycloalkyl group is optionally substituted with one or more substituents independently selected from the group consisting of F, OH, CN, C1-4-alkyl, C1-4-alkyl-O—, (RN)2N, C1-4-alkyl-S(═O)2—, C3-6-cycloalkyl, heterocyclyl, phenyl, and heteroaryl; heterocyclyl is a C4-7-cycloalkyl ring in which one or two —CH2-groups independently are replaced by NRN, O, C(═O), S, S(═O), or S(═O)2; heterocyclyl may be optionally substituted with one or more substituents independently selected from F, C1-4-alkyl, (RN)2N, OH and C1-4-alkyl-O—, and wherein aryl is phenyl or naphthyl; heteroaryl is a 5- or 6-membered aromatic ring which contains 1, 2, or 3 heteroatoms independently selected from N, NRN, O, and S; and each aryl, phenyl, and heteroaryl is optionally substituted with one or more substituents LAr; RNT2 is H or C1-6-alkyl; or RNT1 and RNT2 are linked to form one group selected from an C3-5-alkylene group, wherein one or two —CH2-groups are replaced independently by NRN, O, C(═O), S, S(═O), or S(═O)2, and wherein the ring formed by RNT1 and RNT2 together with the nitrogen atom to which they are attached is optionally substituted with one or more substituents independently selected from F, C1-4-alkyl, (RN)2N—, OH, and C1-4-alkyl-O—; LAr is selected from the group consisting of F, Cl, Br, I, CN, OH, NO2, C1-4-alkyl-, cyclopropyl, C1-4-alkyl-O—, (RN)2N—C(═O)—, (RN)2N—, and C1-4-alkyl-S(═O)2—, wherein each alkyl group is optionally substituted with one or more substituents independently selected from F, Cl, CN, OH, and C1-3-alkyl-O—; LP is selected from the group consisting of F, C1-3-alkyl, F3C—, and C1-3-alkyl-O; LQ is selected from the group consisting of F, Cl, CN, OH, NO2, C1-4-alkyl, C3-7cycloalkyl-, F2HC—, F3C—, C1-4-alkyl—O—, F2HC—O—, F3C—O—, —NH2, and C3-7-cycloalkyl-O—; m is 0, 1, 2, 3, or 4; and n is 0, 1, 2, 3, or 4; or a salt thereof wherein the compound does not include 4-{Cyclopropyl-[4-(4-methyl-oxazol-5-yl)-benzoyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester. |
