发明名称 |
combinação de um inibidor polimerase nucleosídeo com um inibidor protease macrocíclico e uso do mesmo no tratamento de hepatite c, fibrose hepática e função de fígado prejudicada |
摘要 |
Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. |
申请公布号 |
BRPI1009338(A2) |
申请公布日期 |
2016.11.01 |
申请号 |
BR2010PI09338 |
申请日期 |
2010.02.26 |
申请人 |
F. HOFFMANN-LA ROCHE LTD.;PHARMASSET, INC.;ROCHE PALO ALTO LLC |
发明人 |
ABEL DE LA ROSA;ELLEN S. YETZER;MICHAEL D. ROGERS;PATRICK F. SMITH;STEVEN B. PORTER;WILLIAM T. SYMONDS;WILLIAMSON ZIEGLER BRADFORD |
分类号 |
A61K31/4709;A61K31/7068;A61P1/16;A61P31/14 |
主分类号 |
A61K31/4709 |
代理机构 |
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地址 |
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