| 摘要 |
<p>A composition for use in the preparation of a bone-scanning agent comprises a mixture of a bis-phosphonic acid of formula (I), wherein R?1 and R3¿ may be the same or different group selected from H, -SO¿3?H and a lower aliphatic group which may optionally contain one or more hetero atoms and which contains at least one -SO3H group; R?2¿ is a group selected from H, -OH, -NH¿2?, -NHMe, -NMe2 and lower alkyl optionally substituted by one or more polar groups; R?4¿ is a group selected from H, -OH, -NH¿2?, -NHMe, -NMe2, -SO3H and a lower alkyl optionally substituted by one or more polar groups; and n is 0 or 1; with the proviso that when n is 0, R?1¿ is not H and that when n is 1, R?1 and R3¿ cannot both be H; or a non-toxic salt thereof, together with a reducing agent for pertechnetate ions. Technetium-99m, as an aqueous solution of pertechnetate ions, is added to the composition to form a complex of Tc-99m, and the bisphosphonate. The complex is useful as a bone-scanning agent and is rapidly taken up in bone to give scans of high definition.</p> |
