| 摘要 |
PROBLEM TO BE SOLVED: To provide an integrin αvβ8 antagonist for reducing the transforming growth factor-β (TGFβ) activation in an individual, to provide an anti-αvβ8 antibody or immuno conjugate, further to provide compositions containing one of αvβ8 antagonist, anti-αvβ8 antibody, or immuno conjugate, to provide methods for using the compositions, and to provide related objects.SOLUTION: An isolated antibody specifically binding to αvβ8 has a heavy chain variable region comprising the CDR-1 sequence of a specific sequence, the CDR-2 sequence of a specific sequence, and the CDR-3 sequence of a specific sequence, as well as the CDR-1 sequence of a specific sequence, the CDR-2 sequence of a specific sequence, in which Xaa is tyrosine, and the CDR-3 sequence of a specific sequence, preferably being a monoclonal antibody. In the antibody, isotype is IgG1, IgG2, IgG3, or IgG4. Preferably, the antibody is a human antibody or a humanized antibody.SELECTED DRAWING: None |
