PROCESS FOR PREPARING PYRIMIDONE DERIVATIVES

摘要

Pyrimidinone derivs. of formula (I) [R1=halogen or NO2; R2= C1-4 alkyl; R3=C1-3 alkylene; R4=pyridyl, alkylpyridyl, N-oxidopyridyl, N- oxidoalkylpyridyl and their salt, useful as antihistaminics, are prepd. Thus, a mixt. of 5-bromo-2-(4-aminobutyl)-3-methylpyridine and 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone in pyridine was refluxed to give (I) (R1=Br, R2=Me, R3=CH2CH2, R4=6- methyl-3-pyridyl).