| 发明名称 |
PROCESS FOR THE PREPARATION OF 2-HALONICERGODINE DERIVATIVES AND THEIR ACID ADDITION SALTS |
| 摘要 |
<p>The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), <IMAGE> (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), <IMAGE> (II) wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong alpha -adrenerg blocking and calcium-antagonistic action.</p> |
| 申请公布号 |
IN163116(B) |
申请公布日期 |
1988.08.13 |
| 申请号 |
IN1986CA43019 |
申请日期 |
1986.06.10 |
| 申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT |
发明人 |
KISS BELA;LASZBOVSZKY ISTVAN DR.;LAPIS ERZAEBET;KARPATI EGON DR.;SZOMBATHELYI ZSOLT DR.;SZPORNY LASZLO DR.;TRISCHLER FERENC DR.;PALOSI EVA DR.;GROO DORA DR.;BOGSCH ERIK;GALAMBOS JANOS DR.;KASSAI ANNA NEE ZIEGER;MEGYERI GABOR DR.;KEVE TIBOR DR.;STEFKO BELA DR. |
| 分类号 |
A61K31/48;A61P3/00;A61P3/14;A61P9/00;A61P25/02;A61P25/28;C07D457/02;(IPC1-7):C07D401/14 |
主分类号 |
A61K31/48 |
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