| 摘要 |
The present invention relates to a pharmaceutical composition in a multiple-unit dosage granular form comprising quinidine salt as a therapeutically active compound, and intended to be administered once per 24 hrs, whereby the composition releases quinidine salt in accordance with US Pharmacopea Standards (USP XXI, apparatus 2, 75 rpm) in an artificial gastric juice having pH 1.2 to an extent of less than 30% after 2 hrs of exposure; and releases according to the same Statndard in a phosphate buffer having pH 6.8 to an extent of more than 25%, but less than 90% after 3 hrs of exposure in said phosphate buffer, pH 6.8, (a total exposure of 5 hrs) and releases more than 60% after 8 hrs of exposure (a total of 10 hrs of exposure); and releases less than 100% after 4 hrs of exposure (a total of 6 hrs of exposure) in said phosphate buffer; and releases quinidine salt to an extent of more than 90% after 12 hrs of exposure (a total of 14 hrs of exposure) in said phosphate buffer. |
