Methods and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation

摘要

Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.

主权项

1. Apparatus for stenting comprising:
a balloon-expandable stent having proximal and distal ends, and a lumen extending therebetween, a tubular body with a wall having a web structure configured for expansion from a collapsed delivery configuration to an expanded deployed configuration; the web structure comprising a plurality of interconnected, neighboring web patterns, each web pattern having a plurality of adjoining webs, each adjoining web consisting essentially of a central section interposed between first and second lateral sections, each adjoining web has a substantially uniform length, wherein within each adjoining web the first lateral sections joins the central section at a first obtuse angle less than 180°, and the second lateral section joins the central section at a second obtuse angle less than 180°, and in the expanded deployed configuration each central section has a longitudinal axis disposed at an oblique angle relative to a longitudinal axis of the tubular body of the stent, longitudinal axes of adjacent central sections, circumferentially disposed about a web pattern of the plurality of web patterns, intersect, and adjacent ones of the neighboring web patterns, adjacently disposed along the longitudinal axis of the tubular body of the stent, have alternating concavity; a biocompatible material layer, the biocompatible material layer including a material and attached to at least a portion of the stent between the proximal and distal ends, the biocompatible material layer comprising pores along its entire length, the pores having a uniform size, wherein the biocompatible material layer is attached to the stent along discrete points or defined planes, and wherein the biocompatible material layer comprises a porous woven, knitted or braided material.