主权项 |
1. A method of imaging a carcinoma that expresses a folate receptor comprising the steps of:
a. administering to a patient in need of an effective amount of a compound capable of binding to a cancerous cell having the formula:or a pharmaceutically acceptable salt or isotope thereof, wherein: X is an single amino acid or a single amino acid derivative thereof, wherein the single amino acid or single amino acid derivative contains an —OH, —NH2, or —SH functional group, and Y is a dye that has a fluorescence excitation and emission spectra in the near infra-red range, wherein Y is represented by the formula:wherein, R1 is independently selected from the group consisting of O, S, N and C, and R2 is independently selected from the group consisting of CH2 and CH2CH2, and the compound enhances the fluorescence of the dye, Y; and
b. fluorescent imaging of an area of concern in the patient's body where the compound has been bound to a cancerous cell wherein the carcinoma is selected from the group consisting of cervical cancer, ovarian cancer, breast cancer, leukemia cancer, and lung cancer. |