Cyclodextrin derivatives and processes for preparing same.

摘要

Partially methylated carboxyacyl-cyclodextrins of the general formula (I), <CHEM> wherein A means the cyclodextrin skeleton of the general formula (II) <CHEM> containing the substituents in the position labelled by the wavy line; W stands for an alkylene, alkenylene or arylene group or the substituted derivatives thereof; R means hydrogen, an alkyl, aryl or aralkyl group; m is 6, 7 or 8; n is an integer from 1 to 2m; and p is 2m-n+z, wherein the value of z is from 0 to 3 as well as their salts induce less haemolytic effect than the cyclodextrin compounds used as starting materials. They may be used to enhance the water solubility of pharmaceutically-active compounds.