| 摘要 |
An aminoglycoside compound represented by the following formula (I) <IMAGE> (I) wherein one of R1 and R2 represents a hydrogen atom, and the other represents a methyl group, R3 represents a hydrogen atom or a hydroxyl group, R4 represents a hydrogen atom, a hydroxyl group or a methoxy group, n represents an integer of 1 to 5, W represents a divalent group of the formula -NHCO->, -CONH->, -COO->, or -S-> in which-> represents a bond to X, and X represents (i) a single bond or (ii) a C1-C20 trivalent acyclic saturated hydrocarbon group, and Y and Z are separately defined according to the cases (i) and (ii) above, and its pharmaceutically acceptable acid addition salt; and a process for producing the above aminoglycoside compound. A pharmaceutical composition comprising the above aminoglycoside compound is useful as an antibiotic.
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