METHOD OF NEW ACYL DERIVATIVES PRODUCTION

摘要

3-Quinolonyl carbonyloxymethyl - cephalosporin derivs. of formula (I), their easily hydrolysed esters and salts, opt. as hydrates, are new: m = O-2; R1 = H or acyl; R2 = H, lower alkoxy, NH2, lower alkylthio or low alkanoylamino; R31 = H, lower alkyl (opt. halo substd.), lower alkenyl, 3-7C cycloalkyl or halophenyl; Z = R30C or N; R30 = H or halo, or R30 and R31 together form 3-5C alkylene, 2-4C alkyleneoxy or 1-2C alkylenedioxy; R32 = H, halo, lower alkyl or opt. substd. 5 0r 6-membered heterocycle with 1-3 O, N and/or S; R33 = H or halo, or R32 and R33 together form 1-4C alkylene dioxy.