Targeted nanoparticles

摘要

Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

主权项

1. A targeted nanoparticle comprising a mucic acid-containing polymer, a therapeutic agent, and a polymer containing a nitrophenylboronic acid, said nitrophenylboronic acid being coupled to the mucic acid-containing polymer with a reversible covalent linkage, said targeted nanoparticle being configured to present the polymer containing the nitrophenylboronic acid to an environment external to the targeted nanoparticle, wherein the polymer containing the nitrophenylboronic acid is conjugated to a targeting ligand at its terminal end opposite the targeted nanoparticle, wherein the targeted nanoparticle has one molecule of targeting ligand per targeting nanoparticle.