DIPHOSPHONIC ACID DERIVATIVES PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Diphosphonic acid derivs. of formula (I) and their pharmaceuticlly acceptable salts are prepared. In (I), Het is imidazol, imidazolin, (iso)oxazol, oxazolin thiazol, thiazolin, triazol, oxadiazol or thiadiazol; Y is H or lower alkyl; X is amino substd. by H, OH or lower alkyl; R is H or lower alkyl. (I) are useful as calcium complexing agents for treating metabolic bone.