Anthracycline derivatives having cytostatic activity

摘要

The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I, which are optionally in the form of a salt of an inorganic or organic acid, <IMAGE> I in which the substituents have the following meaning: R1 is hydrogen or a hydroxyl group, R2 is hydrogen or a hydroxyl or a methoxy group, R3 is hydrogen or a hydroxyl group, R4 is hydrogen or a hydroxyl group, R5 is hydrogen, a hydroxyl or a methoxycarbonyl group, or a substituent of the general formula II, <IMAGE> II in which R8a has the meaning indicated for R8, or a substituent of the formula III, <IMAGE> III R6 is ethyl, methylcarbonyl, hydroxymethylcarbonyl, hydroxyalkyl or a dihydroxyalkyl, R7 is hydrogen or a substituent of the general formula IV, <IMAGE> IV and R8 is hydrogen or a cyanomethyl group or a substituent of the general formula COR9 or CH2R10, R9 being hydrogen, CH3, CF3 or CCl3, and R10 being C1- to C8-alkyl, substituted alkyl, phenyl or substituted phenyl, to a process for their preparation and to their use in pharmaceuticals.