| 摘要 |
A thioformamide derivative of the formula: I wherein R represents alkyl, A represents optionally substituted pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno¢2,3-b!pyridin-5-yl, pyrazin-2-yl, indol-3-yl, thieno¢3,2-b!pyridin-6-yl, or phenyl and Y represents a valency bond, methylene or ethylene, R2 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryloxyalkyl, aromatic heterocyclylalkyl or aromatic heterocyclyloxyalkyl group or a group BC(=O)- or BSO2 - in which B represents optionally substituted alkyl, aryl, or aromatic heterocyclic, n represents 0 or 1, and when n represents 0 R1 may represent a hydrogen atom, optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryloxyalkyl, aromatic heterocyclylalkyl or aromatic heterocyclyloxyalkyl group or a group BC(=O)-, and when n represents 1 R1 represents optionally substituted alkyl, benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrld-3-ylmethyl radical and pharmaceutically acceptable salts thereof possess pharmacological properties.
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