| 摘要 |
<p>The indolocarbazoles represented by formula (I) wherein Ra and Rb are each H or Ra and Rb taken together are A or B wherein R1 and R2 are independently H or OH or OCH3 and R3 is OH, NHCH3, NCH3 COCH3 or NHCOCH3 and R4 is OH or H and, stereochemical isomers thereof or pharmaceutical compositions thereof useful for inhibiting myosin light chain kinase, protein kinase C or tumor cell proliferation as well as producing an antihypertensive effect and an anti-inflammatory effect in warm-blood animals such as man are disclosed with the provisos that (1) when Ra and Rb together are A, and R1=H or OH, R3 is not NHCH3; (2) when Ra and Rb together are B, then R1=R4=H; (3) when Ra=Rb=H R1=-OCH3, and (4) when Ra and Rb taken together are A, and R1=H, R3 is not (II).</p> |
