| 摘要 |
The invention relates to new phenylethanolaminomethyltetralins having the following formula (I) <IMAGE> in which - E represents hydrogen, a (C1-C4)alkyl group, a (C1-C4)alkoxy group, a phenyl group, a nitro group, a halogen atom or a trifluoromethyl group, - L represents hydrogen, a (C1-C4)alkyl group, a (C1-C4)alkoxy group, a nitro group or a halogen atom, or - E and L, together, represent a -CH=CH-CH=CH or -CH2-CH2-CH2-CH2- group, and - G represents a hydrogen atom, a chloro atom, a hydroxyl group or a group -OG' where G' represents a (C1-C4)alkyl group which is unsubstituted or substituted by a hydroxyl, (C1-C4)alkoxy, (C1-C4)alkoxycarbonyl, carboxyl, or (C3-C7)cycloalkyl group, the carboxyl group being free or esterified by a metabolically labile group; a (C3-C7)cycloalkyl group; or a (C2-C4)alkanoyl group, and to their salts, which have a selective beta-adrenergic activity on the intestines. The invention also relates to a process for the preparation of these compounds and the intermediates of formula (III) <IMAGE> useful in this process.n
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