发明名称 |
Lipid A analogues having immunoactivating and anti-tumour activity. |
摘要 |
<p>Compounds of formula (I): <CHEM> [in which: R<1> is hydroxy, protected hydroxy, fluorine, or -OP(O)(OH)2; R<2> and R<3> are independently optionally substituted C6 - C20 aliphatic acyl; R<4> is hydroxy, protected hydroxy, or -OP(O)(OH)2, where at least one of R<1> and R<4> is -OP(O)(OH)2; and R<5> is hydroxy, protected hydroxy, or fluorine; provided that, except where at least one of R<1> and R<5> is fluorine, then at least one of R<2> and R<3> is a substituted C6 - C20 aliphatic acyl having (i) at least one halogen substituent and (ii) at least one of halogen, hydroxy and C6 - C20 aliphatic acyloxy or at least one of R<2> and R<3> is a substituted C6 - C20 aliphatic acyl which is substituted by at least one halogen-substituted C6 - C20 aliphatic carboxylic acyloxy]; have Lipid A-like activity and may be used for the treatment, prophylaxis, diagnosis and support of an animal suffering a disease or disorder arising from a deficiency in the immune system or from a tumor. They may be prepared by phosphorylation of corresponding compounds lacking a phosphoryl group.</p> |
申请公布号 |
EP0437016(A2) |
申请公布日期 |
1991.07.17 |
申请号 |
EP19900307045 |
申请日期 |
1990.06.27 |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
SHIOZAKI, MASAO, C/O SANKYO COMPANY LIMITED;ISHIDA, NOBORU, C/O SANKYO COMPANY LIMITED;KOBAYASHI, TOMOWO, C/O SANKYO COMPANY LIMITED;HIRAOKA, TETSUO, C/O SANKYO COMPANY LIMITED;ARAI, MASAMI, C/O SANKYO COMPANY LIMITED;AKAMATSU, YUZURU, NATIONAL INSTITUTE OF HEALTH;NISHIJIMA, MASAHIRO, NATIONAL INSTITUTE OF HEALTH |
分类号 |
C07H5/06;A61K31/70;C07H11/04;C07H13/06;C07H13/12;C07H15/02;C07H15/10;C07H15/18;(IPC1-7):C07H13/06 |
主分类号 |
C07H5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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