发明名称 3-aryl-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butyramide and derivatives as antifungal agents
摘要 Compounds of the formula <IMAGE> (I) or a pharmaceutically or agriculturally acceptable acid addition salt thereof, wherein R is 5-chloro-2-pyridyl, or phenyl optionally substituted by one to three substituents, each independently selected from F, Cl, Br, I, CF3, C1-C4alkyl and C1-C4alkoxy; R1 is CN, CSNH2 or CONR2R3 where either (a) R2 is H or certain alkyl groups and R3 is H or certain alkyl, substituted alkyl, aralkyl, phenyl or cycloalkyl groups, or (b) R2 and R3 taken together with the nitrogen atom to which they are attached form a nitrogen heterocyclic group, optionally containing an oxygen atom or NR4 group, as a ring member and R4 is H, C1-C4alkyl; C2-C4alkanoyl or (C1-C4alkoxy)carbonyl; R5 and R6 are each H or CH3; methods for their use in combatting fungal infections in plants, seeds and animals, including humans, pharmaceutical and agricultural compositions containing them and intermediates therefor.
申请公布号 US5047548(A) 申请公布日期 1991.09.10
申请号 US19880149031 申请日期 1988.01.27
申请人 PFIZER INC. 发明人 RICHARDSON, KENNETH;GYMER, GEOFFREY E.
分类号 A01N43/653;C07C45/46;C07D249/08;C07D521/00 主分类号 A01N43/653
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