| 摘要 |
Cephalosporin derivs. of formula (I), their pharmaceutically acceptable non-toxic salts and their physiologically hydrolyzable esters and solvates are new. (I) are prepd. by reacting a cpd. of formula (II) with a cpd. of formula (III) in the presence of a solvent. In the formulas, R1 = C1-4 alkyl, C3-4 alkenyl, C3-4 alkynyl or C(Ra)(Rb)COOH; Ra and Rb each = H or C1-4 alkyl; or CRaRb = C3-7 cycloalkyl; R2 = C1-4 alkyl, C3-4 alkenyl or C3-7 cycloalkyl; n = 0 or 1; R3 = H or amino-protecting gp.; R4 = H or carboxyl-protecting gp. (I) exhibit antibacterial activity against Gram-positive and -negative bacteria. (I) have good stability to beta-lactamase.
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