INTERMEDIATES ON THE SYNTHESIS OF 17 BETA-ACYL-3-CARBOXY-ANDROSTA-3,5-DIENES

摘要

18148 TITLE OF THE INVENTION NEW INTERMEDIATES IN THE SYNTHESIS OF 17.beta.-ACYL-3-CARBOXY-ANDROSTA-3,5-DIENES OE THE INVENTION NEW INTERMEDIATES IN THE SYNTHESIS OF 17.beta.-ACYL-3-CARBOXY-ANDROSTA-3,5-DIENES, OF THE FORMULA: 8372/SCM110 18148 wherein R2 is 2-thlopyridyl, and R3 is C2-C4 alkoxycarbonyl, C1-C4, or trifluoromethylsulfonyloxy. The above compounds are useful intermediates in producing testosterone 5.alpha.-reductase inhibitors which are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.