| 摘要 |
PCT No. PCT/DE88/00149 Sec. 371 Date Nov. 13, 1989 Sec. 102(e) Date Nov. 13, 1989 PCT Filed Mar. 11, 1988 PCT Pub. No. WO88/07050 PCT Pub. Date Sep. 22, 1988.The invention relates to a process for the production of (+)-bicyclo[3.3.0]octan-3-one-2 carboxylic acid steroid esters of formula I <IMAGE> (I) in which X means oxygen or the radicals -O-(CH2)n-O- or -O-CH2-C(CH3)2-CH2-O-, n means 2 or 3 R2 means hydrogen or methyl, Y means the radicals X or X1, X1 means the radicals OCH3 or OCOR3, R3 means methyl, ethyl, phenyl, benzyl or pivalyl and the radical <IMAGE> the radicals <IMAGE> <IMAGE> and X and X1 have the meanings indicated above, characterized in that D,L-bicyclo[3.3.0]octan-3-one-2 carboxylic acid esters of formula II <IMAGE> (II) in which X has the meaning indicated above and R is an alkyl group with 1-4 carbon atoms, with optically active steroids with a free 17'beta hydroxy group of formula III <IMAGE> (III) in which R2 and the radical <IMAGE> have the meanings indicated above, in the presence of a nucleophilic or acid catalyst is converted into the diastereomeric steroid esters and the optically pure steroid esters of formula I are obtained as crystallizates.
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