| 摘要 |
<p>Stable polyligands are provided by preparing fused proteins, where the fused protein comprises a ligand at one terminus and a subunit or a multimeric unit protein at the other terminus, where the fused protein is able to assemble to provide a polyligand. The polyligands find use in modulating physiological processes by inhibiting ligand induced signal transduction by surface membrane protein receptors and/or in the case of ν chain use, by complement mediated killing or any other effector functions. The molecule may be composed solely, of human components to avoid an immune response by the recipient.</p> |
