| 摘要 |
<p>The present invention is directed to a material (10) which can be used to deliver a drug, such as an antibiotic, into a diseased tissue pocket (12), such as a periodontal pocket. The material (10) is preferably a bioerodible polymer such as a poly(orthoester), a polylactic acid, a polyglycolic acid or a copolymer or mixture thereof. The polymer containing the drug is heated to a physiologically compatible elevated temperature prior to injection into the tissue pocket (12). Once the bioerodible material (10) is injected into the pocket (12), the material (10) cools to the body temperature of the pocket (12). As it cools, the material (10) hardens and remains in place in the tissue pocket (12). The hardened material (10) bioerodes in the pocket (12) and releases the drug over a period of several days.</p> |
