发明名称 |
MOLECULAR SIEVE-ENCLOSED PARAMAGNETIC ION FOR DIAGNOSIS |
摘要 |
PCT No. PCT/US91/09222 Sec. 371 Date May 27, 1993 Sec. 102(e) Date May 27, 1993 PCT Filed Dec. 6, 1991 PCT Pub. No. WO92/10213 PCT Pub. Date Jun. 25, 1992.The invention relates to a method of using molecular sieve-enclosed paramagnetic ions as image brightening or image contrast agents. In particular, zeolite enclosed trivalent gadolinium is useful in MRI studies of the entire gastrointestinal tract, providing excellent images. Zeolite-enclosed gadolinium complexes may be conveniently administered in oral preparations without side effects of diarrhea. Other transition metal ions, including divalent manganese may be enclosed in any suitable molecular sieve which has ion exchange properties sufficient to exchange the selected metal. The exchanged paramagnetic metal ion may be a free ion within the zeolite framework or ligated with a chelator. Alternatively, a paramagnetic metal ion may be included as part of the molecular sieve framework. |
申请公布号 |
CA2095832(A1) |
申请公布日期 |
1992.06.08 |
申请号 |
CA19912095832 |
申请日期 |
1991.12.06 |
申请人 |
BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (THE);STUART W. YOUNG |
发明人 |
YOUNG, STUART W.;BALKUS, KENNETH J., JR.;SHERRY, A. DEAN |
分类号 |
A61B5/055;A61K49/00;A61K49/18;A61K51/00;A61M25/095 |
主分类号 |
A61B5/055 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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