摘要 |
<p>A fibrinogen based composition is described which is derived from bovine plasma through the use of polyethylene glycol ('PEG') and glycine precipitation techniques. The composition contains highly purified fibrinogen which can be activated and converted to fibrin by the addition of thrombin or by the action of endogenous thrombin in the case of small wound closures for purposes of hemostasis. Additionally the fibrinogen composition provides sufficient strength to be used as a surgical adhesive. A test kit is also provided for detecting allergy to bovine-derived fibrinogen.</p> |