INDOLE DERIVATIVES

摘要

The present invention provides Indole derivatives represented by the formula (I) (I) wherein R1, R2 and R3 independently represent hydrogen or lower alkyl; R4 represents hydrogen, lower alkyl or cycloalkyl; R5 represents hydrogen, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, -CHR7R8 where R7 and R8 independently represent hydrogen, alkyl, alkenyl, alkynyl, substituted or unsubstituted cycloalkyl, -(CH2)mOR9 (wherein m is an integer of 1 - 3 and R9 is lower alkyl), substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, or substituted or unsubstituted thienyl!, (wherein p is an integer of 1 - 3) or (wherein Y is CH2, O, S, CH2-CH2, CH=CH, CH2-CO or CH2-S); R6 represents hydrogen, lower alkyl or lower alkoxy or halogen; X represents O or S(O)q (wherein q is an integer of 0-2); and n represents an integer of 1-6} or pharmaceutically acceptable salts thereof. The compound shows prominent inhibition effects on steroid 5.alpha.-reductase activity, and are useful in treating benign prostatic hypertrophy, prostate cancer, baldness and acne.