| 摘要 |
<p>Compounds having aldose reductase inhibitory activity of formula (I) wherein X CH2, CH2CH2, -CHCH3, (a); Y=O or S; R1 is an optionally substituted phenyl, benzothiazol-2-yl, benzoxazol-2-yl, benzofuran-2-yl, benzothiophen-2-yl, thiazolopyridin-2-yl, oxazolopyridin-2-yl, 3-phenyl 1,2,4-oxadiazol-5-yl, and 5-phenyl-1,2,4-oxadiazol-3-yl wherein said substituted groups are substituted with one or more and preferably two substituents that are independently selected from fluorine, chlorine, bromine, methyl, and trifluoromethyl; R?2 and R3¿ are independently selected from hydrogen, fluorine, chlorine, bromine, (C¿1?-C4) alkyl, methyl (C1-C4) alkylthio, (C1-C4) alkoxy and trifluoromethyl or R?2 and R3¿ taken together with the carbons to which they are attached form a group W, wherein W is (b) or (c) wherein p is 1 or 2 and U?1 and U2¿ are independently CH¿2?, O or S with the proviso that both U?1 and U2¿ are not O or S; R4 is hydrogen or a prodrug group; or a pharmaceutically acceptable salt thereof.</p> |
