发明名称 Clay compositions
摘要 The present invention relates to liquid or semi-solid pharmaceutical compositions, more specifically to aqueous pharmaceutical suspension or semi-solid paste containing natural mineral clays as active ingredients. These compositions are particularly useful for the treatment of acute and chronic diarrhea.
申请公布号 US9511023(B2) 申请公布日期 2016.12.06
申请号 US201113695593 申请日期 2011.04.29
申请人 IPSEN PHARMA S.A.S. 发明人 Hacher Béatrice;Kubiak Didier;Harnett Jeremiah;Mondoly Nathalie
分类号 A61K33/06;A61P1/00;A61K9/10;A61K35/02;G01N17/00;A61K9/00;A61K47/26;A61K47/32;A61K47/38;G01N11/14 主分类号 A61K33/06
代理机构 Hunton & Williams LLP 代理人 Hunton & Williams LLP
主权项 1. A pharmaceutical composition comprising: (i) 30% to 35% by weight (w/w) natural dioctahedral smectite as the only active ingredient; (ii) about 0.1% to about 5% by weight (w/w) xanthan gum; (iii) a pH adjuster; (iv) 0.01% to 5% by weight (w/w) preservative selected from citric acid, potassium sorbate, ascorbic acid, and mixtures thereof; (v) 0.5% to 2% by weight (w/w) flavoring agent; (vi) about 0.02% to 0.5% by weight (w/w) sweetener selected from sodium saccharin, sucralose, a natural sweetener from plant extract, and mixtures thereof; and (vii) water; wherein the pH of the composition is between 4 and 6, the composition has a viscosity of between about 1100 mPa·s and about 2500 mPa·s, and the composition is an aqueous suspension or in a semi-solid state.
地址 Boulogne-Billancourt FR
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